The self-assembly process of biomolecules such as proteins and peptides is widely present in the physiological activities of organisms in nature, and its assemblies have good biocompatibility and controllable assembly functions in organisms, which can achieve aggregation and retention in the lesion area. In order to meet the needs of drug delivery and disease diagnosis and treatment, peptides need to be functionalized. The modification sites mainly include amino and carboxyl groups in the main chain, as well as amino, carboxy, hydroxyl, and sulfhydryl groups in the side chains. The modification of functional molecules can be carried out in a direct or indirect way, including drug molecules, probe molecules, alkyl chains, polymers, sugars, etc., and indirect modification uses linker units to link functional molecules with peptides. The modified self-assembled peptide has greater advantages in assembly capacity and biomedical application and is an effective strategy to solve the problem of poor recognition and enrichment ability of small molecule drugs in the lesion area, easy degradation in the internal circulation, and large toxic side effects on normal cells and tissues.
The peptide modification services at Biotyscience offer a wide range of modifications to meet any research need. These modifications can improve overall peptide stability, alter structure to better understand biological function, or enhance immunogenicity for antibody development and production. In addition to a variety of terminus and internal modifications, Biotyscience's services include peptide labeling and conjugations for imaging and detection needs.
For other services please contact our customer service department.
Website: www.biotyscience.com Phone: + 400-669-8850 Email: biotyscience@gmail.com
1.N-terminal modifications
1-Nap | Benzoyl | DOTA | Maleimide |
2-Nap | Biotin | Fatty Acid | MCA |
3-Mal | Biotin-Ahx | Fatty Acid | Myristoyl |
6-Mal | BOC | FITC-Ahx | Octanoic acid |
5-FAM | Br-Ac- | FITC-PEG2 | OVA (-NH2 of N terminal) |
5-FAM-Ahx | BSA (-NH2 of N terminal) | Fmoc | Palmitoyl |
6-FAM | Cl-Ac | Formylation | PEN |
Abz | CBZ | HYNIC | Rhodamine B |
4-Abz | Dansyl | HYNIC | Stearic acid |
Acetylation | Dansyl-Ahx | KLH (-NH2 of N terminal) | Succinylation |
Acryl | Decanoic acid | Lauric acid | TMR |
Alloc | DTPA | Lipoic acid | |
Aminooxy | D-Lactic acid | L-Lactic acid |
2.C-terminal modifications
AFC | Hydrazine |
AMC | KLH (-COOH of C terminal) |
Amidation | MAPS Asymmetric 2 branches |
BSA (-COOH of C terminal) | MAPS Asymmetric 4 branches |
Bzl | MAPS Asymmetric 8 branches |
Cysteamide | NHEt |
Ester (OEt) | NHisopen |
Ester (OMe) | NHMe |
Ester (OTBzl) | OVA (-COOH of C terminal) |
EDA-Biotin | p-Nitroanilide |
tBu |
3. Other modifications (MAPS, PEGylation, cyclic modifications)
MAPS | PEGylation | Cyclic modifications | Disulfide Bridges | Other |
MAPS Asymmetric 2 branches (C-Terminal) | {PEG1} NH2-(PEG)1- CH2COOH | Head to tail amide cyclic | Random Disulfide Bridge | BOC |
MAPS Asymmetric 4 branches (C-Terminal) | {PEG2} NH2-(PEG)2- CH2COOH | Amide cyclic (Side chain) | Mono Disulfide bridge | tBu |
MAPS Asymmetric 8 branches (C-Terminal) | {PEG3} NH2-(PEG)3- CH2CH2COOH | Stapled peptide (S5/S5) | Double Disulfide bridge | Succinylation |
{PEG4} NH2-(PEG)4- CH2CH2COOH | Stapled peptide (R8/S5) | Triple Disulfide Bridge | Me | |
{PEG5} NH2-(PEG)5- CH2CH2COOH | Mono Thioether Bridge | p-Nitroanilide | ||
{PEG6} NH2-(PEG)6- CH2CH2COOH | Thioester (C-terminal) | p-Nitroanilide | ||
{PEG11} NH2-(PEG)11- CH2COOH | Dimer (Inter-Disulfide bridge) | |||
{PEG12} NH2-(PEG)12- CH2CH2COOH | {PEG12} NH2-(PEG)12- CH2CH2COOH | {PEG12} NH2-(PEG)12- CH2CH2COOH | {PEG12} NH2-(PEG)12- CH2CH2COOH |
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Ordering Information
Website: en.biotyscience.com
Phone: +86-400-669-8850
Email: biotyscience@gmail.com