Recombinant Human gp130/IL6ST protein,His-Recombinant Protein-Biotyscience

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Recombinant Human gp130/IL6ST protein,His

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Cat No	ADMD-068
Conjugate
Type	重组蛋白
Source	HEK293
Tag	His
Size	1mg
Application	Immunology
Format	Liquid
Purity	>95 %, SDS-PAGE
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS
Species	Human
Storage	Store at -20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	CD130, CDw130, gp130, IL-6R beta, IL-6RB, IL6ST
Purification	Protein A/G
Note	For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
MolecularWeight	68.5 kDa
Description
Background	Glycoprotein 130 (gp130, also known as IL6ST, CD130 or IL6-beta) is a ubiquitously expressed, signal-transducing receptor that serves as the signal transduction unit for IL-6 family of cytokines, including IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), OSM, ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1), and cardiotrophin-like cytokine (CLC). These cytokines signal through the gp130/Jak/STAT pathway. Binding of IL-6 to IL-6R induces gp130 homodimerization and formation of a high-affinity receptor complex, which activates Jaks. That causes phosphorylation of gp130 tyrosine residues which in turn activates STAT3. gp130 is a type I transmembrane protein, and can also exist as a soluble form (sgp130). sgp130 binds to sIL-6R/IL-6 complexes and prevents their interactions with membrane-anchored gp130 on target cells.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Human gp130/IL6ST protein,His