Bispecific antibodies can target two different antigens at the same time, such as simultaneously binding tumor cell receptors and recruiting cytotoxic immune cells. Structural diversity has been fast-growing in the bispecific antibody field, creating a plethora of novel bispecific antibody scaffolds, which provide great functional variety[1]. The bispecific antibody can override the specificity of an effector cell for its natural target and redirect it to kill a target that it would otherwise ignore. Different cytotoxic cells express different triggering molecules (receptors). Thus, by varying the specificities of target and effector binding domains a variety of effector responses can be directed against most types of target cells. Alternatively, the full range of effector functions (i.e. ADCC, phagocytosis, complement activation and extended serum half-life) can be conferred by targeting one binding specificity to serum immunoglobulin[2].
After years of research and technological development, many different design strategies for bispecific antibodies have emerged in structure. According to whether they contain Fc functional regions, they are mainly divided into two categories: bispecific antibodies containing Fc region and bispecific antibodies without Fc region. Biotyscience is committed to the research and development of genes, recombinant proteins, antibodies, phage libraries and other biologics, and is committed to providing customers with one-stop CRO technical services.
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1.Gene synthesis and codon optimization
Starting from antibody sequence
2.Vector construction
2.1 Cloning into expression vectors
2.2 Plasmid sequencing
2.3 Plasmid production
3.Expression and purification
3.1 Transient transfection of HEK293/CHO cells
3.2 Antibody purification
3.3 Polishing if needed
4.QC analysis
SDS-PAGE and UV analysis
Guarantee high success rate and fast delivery speed;
Service: reasonable price, according to the comprehensive analysis of customer needs, to provide customers with satisfactory results;
Professional technical support, ensure strong, thoughtful and timely pre-sales and after-sales service support, at any time for you to answer any questions;
Complete upstream and downstream services: Provide one-stop technical services from antibody preparation, antibody sequencing, antibody labeling and modification, saving customers valuable time and funds.
High freeze-thaw stability, in vivo half-life of 2-3 weeks, effectively control the risk of immunogenicity;
Unique and flexible molecular properties enable fine regulation of dual target action for better efficacy.
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