Content
Contact us
Biotyscience Inc
E-mail biotyscience@gmail.com
info@biotyscience.com
Tel 400-669-8850
Recombinant Human PDGFR beta protein,Myc,His
- Description
- Documentation
- Citations
| Cat No | ADMD-081 |
| Conjugate | |
| Type | 重组蛋白 |
| Source | HEK293 |
| Tag | Myc,His |
| Size | 1mg |
| Application | Immunology |
| Format | Liquid |
| Purity | >90 %, SDS-PAGE |
| Concentration | Please refer to the vial lable for the specific concentration. |
| Buffer | Supplied in PBS |
| Species | Human |
| Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
| Synonyms | CD140B, JTK12, PDGF R beta, PDGFR, PDGFR beta, PDGFR1, PDGFRB |
| Purification | Protein A/G |
| Note | For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. |
| MolecularWeight | 58.8 kDa |
| Description | |
| Background | Multiple receptor tyrosine kinases and their growth factor ligands have been implicated in cancer progression and metastasis. Among these are the platelet-derived growth factor receptors (PDGFRs). Expression of PDGFRs is mainly restricted to mesenchymal cell types. PDGF is composed of homo-dimers or hetero-dimers of two polypeptide chains, denoted A and B. The two receptor subtypes show different affinities for the dimeric PDGF isoforms. In epithelial tumors, the platelet-derived growth factor receptor B (PDGFRB, also known as PDGFR beta) is mainly expressed by stromal cells of mesenchymal origin. it has also been shown that PDGFRB is also associated with the aggressive behavior of several types of tumors. The 60% of colon cancer patients express high levels of this gene and the PDGFRB expression correlates with lymphatic dissemination of this cancer. Furthermore, PDGFRB signaling in mesenchymal-like tumor cells (as colorectal cancer cells) contributes to invasion and liver metastasis formation. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.