Biotyscience Inc
E-mail biotyscience@gmail.com
info@biotyscience.com
Tel 400-669-8850
Cat No | ADMD-087 |
Conjugate | |
Type | 重组蛋白 |
Source | HEK293 |
Tag | His |
Size | 1mg |
Application | Immunology |
Format | Liquid |
Purity | >95 %, SDS-PAGE |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS |
Species | Human |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | CD71, p90, T9, TFR, TFR1, TFRC, TR, Transferrin R, TRFR |
Purification | Protein A/G |
Note | For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. |
MolecularWeight | 76 kDa |
Description | |
Background | CD71 also known as transferrin receptor protein 1 (TfR1), is a transmembrane glycoprotein composed of two disulfide-linked monomers. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex that enters the cell by endocytosis. CD71 is almost ubiquitously expressed, with the highest expression levels on some cells and tissues, including immature erythroid cells, placental tissue, and rapidly dividing cells. CD71 is involved in iron (Fe3+) uptake, and expression is regulated by the metabolic demand for iron. CD71 is present in actively proliferating cells and is essential for iron transport into proliferating cells. |