Recombinant Mouse B7-2/CD86 protein,His-Recombinant Protein-Biotyscience

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Recombinant Mouse B7-2/CD86 protein,His

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Cat No	ADMD-092
Conjugate
Type	重组蛋白
Source	HEK293
Tag	His
Size	1mg
Application	Immunology
Format	Liquid
Purity	>95 %, SDS-PAGE
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS
Species	Mouse
Storage	Store at -20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	B70, B7-2, CD28LG2, CD86, LAB72, MGC34413
Purification	Protein A/G
Note	For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
MolecularWeight	26 kDa
Description
Background	CD86 (also known as B7-2) is a costimulatory molecule belonging to the immunoglobulin (Ig)superfamily. CD86 is primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, and macrophages.CD86 has strong structural similarity with another B7 family molecule, CD80(B7-1).CD86 and CD80 are the ligands for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte antigen 4 (CTLA-4). Binding of CD86 or CD80 with CD28 antigen is a costimulatory signal for T cell activation, proliferation, and cytokine production. Binding of CD86 or CD80 with CTLA-4 negatively regulates T cell activation and diminishes the immune response.However, CD86and CD80 bind to CTLA-4 with higher affinity than CD28. Defects in CTLA-4-mediated transendocytosis of CD86 are associated with autoimmunity.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Mouse B7-2/CD86 protein,His