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Cat No | BIOP1972 |
Conjugate | |
Type | TNF |
Source | E. coli |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 20mM PB, 150mM NaCl, pH 7.4. |
Species | Mouse |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Tumor necrosis factor ligand superfamily member 11;Tnfsf11;Osteoclast differentiationfactor;ODF;Osteoprotegerin ligand;OPGL;Receptor activator of nuclear factor kappa-Bligand;RANKL;TNF-related activation-induced cytokine;TRANCE;CD254 |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 137-316 |
Background | Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor(TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such asthymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involvedin a number of fundamental biological processes such as acting as regulator of interactions between T-cells anddendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption inhumoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cellproliferation. |