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Cat No | BIOP1976 |
Conjugate | |
Type | TNF |
Source | HEK293 |
Tag | His |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS, pH 7.4. |
Species | Mouse |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Tumor necrosis factor ligand superfamily member 4;TNFSF4;CD134 ligand;CD134L;CD252;CD252 antigen;OX40 antigen ligand;OX40 ligand;OX40L;TAX transcriptionally-activatedglycoprotein 1;tumor necrosis factor (ligand) superfamily;member 4 |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 51-198 |
Background | OX40 ligand (OX40L), also called CD252, is a single-pass type II membrane protein of the TNF/TNF receptorsuperfamily. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival andfor the generation of memory T cells from activated effector T cells. OX40L – OX40 co-stimulation leads toactivation of TNF receptor associated factor (TRAF) 2, 3 and 5. This pathway has been shown to prolong thesurvival of effector CD4+Th cells as well as contributes to generation of memory T cells. |