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Recombinant Mouse IL-23 (IL-23A&IL-12B) Protein(aa 22-196)

Cat NoBIOP2112
Conjugate
Type白介素
SourceHEK293
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS, pH 7.4.
SpeciesMouse
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsSGRF;IL-23p19;CLMF p40;IL-12 subunit p40;NKSF2
Purification> 95% by SDS-PAGE.
MolecularWeight
Descriptionaa 22-196
BackgroundInterleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit thatis unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologousto the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activatedmacrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cellsexpress p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts onboth naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.