Recombinant Human Frizzled-1 Protein(aa 73-253), Fc-His-Recombinant Protein-Biotyscience

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Recombinant Human Frizzled-1 Protein(aa 73-253), Fc-His

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Cat No	BIOP2520
Conjugate
Type	其他蛋白
Source	HEK293
Tag	Fc-His
Size	20 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4.
Species	Human
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	DKFZp564G072;FLJ95923;frizzled family receptor 1;frizzled homolog 1;frizzled;Drosophila;homolog of;1;Frizzled1;Frizzled-1;fz-1;FZD1;fzE1;hFz1;seven transmembrane spanning receptor;Wnt receptor
Purification	> 92% by SDS-PAGE.
MolecularWeight
Description	aa 73-253
Background	This protein belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

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Recombinant Human Frizzled-1 Protein(aa 73-253), Fc-His