Recombinant Human FLT3L/Flt3 ligand/FLT3LG Protein(aa 27-185), His-Recombinant Protein-Biotyscience

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Recombinant Human FLT3L/Flt3 ligand/FLT3LG Protein(aa 27-185), His

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Cat No	BIOP3368
Conjugate
Type	细胞因子
Source	HEK293
Tag	His
Size	10 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4.
Species	Human
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	FL;FLT3L;FLT3LG
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description	aa 27-185
Background	FLT3LG, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors .FLT3LG is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts. Alternate splicing of human FLT3LG also generates membrane-associated isoforms that contain either a truncated cytoplasmic tail or an 85 aa substitution following the cytokine domain. Both transmembrane and soluble FLT3LG signal through the tyrosine kinase receptor Flt-3/Flk-2. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. It synergizes with IL-3, GM-CSF, and SCF to promote the mobilization and myeloid differentiation of hematopoietic stem cells. It cooperates with IL-2, -6, -7, and -15 to induce NK cell development and with IL-3, -7, and -11 to induce terminal B cell maturation.

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Recombinant Human FLT3L/Flt3 ligand/FLT3LG Protein(aa 27-185), His