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Recombinant Protein

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Recombinant Human FLT3 Protein(aa 1-541), His

Cat NoBIOP3384
Conjugate
Type细胞因子
SourceHEK293
TagHis
Size50 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS, pH 7.4.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsCD135;FLK-2;FLK2;STK1;FLT3
Purification> 85 % by SDS-PAGE.
MolecularWeight
Descriptionaa 1-541
BackgroundThis protein is a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
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