Recombinant Human IFN-alpha/beta R1 Protein(aa 28-436), His-Recombinant Protein-Biotyscience

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Recombinant Human IFN-alpha/beta R1 Protein(aa 28-436), His

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Cat No	BIOP3623
Conjugate
Type	药物靶点
Source	HEK293
Tag	His
Size	10 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in 20mM PB, 150mM NaCl, pH 7.2.
Species	Human
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	Interferon Alpha/Beta Receptor 1;IFN-R-1;IFN-Alpha/Beta Receptor 1;Cytokine Receptor Class-IIMember 1;Cytokine Receptor Family 2 Member 1;CRF2-1;Type I Interferon Receptor 1;IFNAR1;IFNAR
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description	aa 28-436
Background	The Interferon-α/β Receptor 1 (IFN-α/β R1) is a receptor which binds Type I Interferons including Interferon-αand - β . It is a cell surface receptor and heteromeric receptor composed of one chain with two subunitsreferred to as IFNAR1 and IFNAR2. IFN- α / β R1, in association with IFN- α / β R2, is required for propagatingantiviral signal transduction triggered by IFN- α and IFN- β . IFN- α / β R1 interacts very weakly or not at all withtype 1 interferons and does not stably interact with IFN- α / β R2. Ligands associate with IFN- α / β R2, and thiscomplex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γR2 even in the absence of IFN- γ stimulation. Human IFN- α / β R1 contains a nuclear localization signal in itsextracellular domain that is required for receptor translocation to the nucleus following interaction withligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Human IFN-alpha/beta R1 Protein(aa 28-436), His