Recombinant Human GUCY2C/Guanylyl cyclase Protein, His-Avi-Recombinant Protein-Biotyscience

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Recombinant Human GUCY2C/Guanylyl cyclase Protein, His-Avi

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Cat No	BIOP3849
Conjugate
Type	药物靶点
Source	HEK293
Tag	His-Avi
Size	50 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4.
Species	Human
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	GUCY2C;GUC2C;STAR;STA receptor;hSTAR;GC-C
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description
Background	GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer. GUCY2C may represent a new target for anti-obesity pharmacotherapy.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Human GUCY2C/Guanylyl cyclase Protein, His-Avi