Mouse Anti-Thrombomodulin Monoclonal Antibody, Clone T88, det-Antibody Pairs-Biotyscience

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Mouse Anti-Thrombomodulin Monoclonal Antibody, Clone T88, det

Description
Documentation
Citations

Cat No	BIOS-2146-D
Conjugate
Type	抗体对
Clone	T88
Source	Mouse
Size	1 mg
Application	Immunology
ApplicationNote	Recommended Antibody pairs:BIOS-2146-C- BIOS-2146-D
Format	Liquid
Purity	>90%
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS; pH 7.4.
Storage	Store at -80 degree for long term.
Synonyms	Thrombomodulin;THBD;TM;Fetomodulin;CD141;THRM
Purification	SDS-PAGE
MolecularWeight
Description
Background	Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Human Thrombomodulin/THBD predicts a signal peptide and a mature chain that consists of following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer. For example, increased serum levels of THBD, due to protease cleavage, have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis.

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