Rabbit anti-Human Human IgM Monoclonal Antibody-Monoclonal Antibody-Biotyscience

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- ELISA Kit
  - --|--|Conjugation Kit
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Bioparticles
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  - --|--|Gold Nanoparticles
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  - --|--|Magnetic Particles Conjugates
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  - --|--|Conjugation Kit
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- Monodisperse Particles
  - --|--|Polystyrene Particles
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  - --|--|PBS Particles
- Other Particles
  - --|--|Upconverting Nanoparticles
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  - --|--|Chromatography Media
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Rabbit anti-Human Human IgM Monoclonal Antibody

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Documentation
Citations

Cat No	BMA-1875
Conjugate
Type	重组兔多抗
Source	Rabbit
Size	50 uL
Application	Immunogen
Format	Liquid
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Species	Human
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Synonyms	AGM1;MU;VH
Purification	Affinity purification
MolecularWeight	80KDa
Description
Background	Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes, joining (J) genes, and diversity (D) genes. The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Rabbit anti-Human Human IgM Monoclonal Antibody