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Rabbit anti-Human Troponin I1/TnI1 Monoclonal Antibody
- Description
- Documentation
- Citations
| Cat No | BMA-2186 |
| Conjugate | |
| Type | 重组兔多抗 |
| Source | Rabbit |
| Size | 50 uL |
| Application | WB |
| Format | Liquid |
| Concentration | Please refer to the vial lable for the specific concentration. |
| Buffer | Supplied in PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Species | Human |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Synonyms | SSTNI;TNN1 |
| Purification | Affinity purification |
| MolecularWeight | 22KDa |
| Description | |
| Background | Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.