Rabbit anti-Human Chk2 Monoclonal Antibody-Monoclonal Antibody-Biotyscience

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Antibodies
- Primary Antibodies
  - --|--|Monoclonal Antibody
  - --|--|Polyclonal Antibody
  - --|--|Small Molecule Antibody
  - --|--|Antibody Pairs
- Secondary Antibodies
- ELISA Kit
  - --|--|Conjugation Kit
Protein
Bioparticles
- Metal Nanoparticles
  - --|--|Gold Nanoparticles
  - --|--|Gold Nanorods
  - --|--|Silver Nanoparticles
  - --|--|Gold NanoUrchins
  - --|--|Carbon Nanoparticles
  - --|--|Special Shape Particles
- Magnetic Particles
  - --|--|PS Magnetic Particles
  - --|--|Silica Magnetic Particles
  - --|--|Fe3O4 Magnetic Particles
  - --|--|Functionalized Magnetic Particles
  - --|--|Magnetic Particles Conjugates
  - --|--|Fe2O3 Magnetic Particles
  - --|--|Magrose Magnetic Particles
  - --|--|UF Magnetic Particles
  - --|--|Conjugation Kit
  - --|--|Other Magnetic Particles
  - --|--|Magnetic Separation
- Monodisperse Particles
  - --|--|Polystyrene Particles
  - --|--|Silica Particles
  - --|--|PMMA Particles
  - --|--|PET Particles
  - --|--|PVA Particles
  - --|--|PVC Particles
  - --|--|DVB Particles
  - --|--|PP Particles
  - --|--|PE Particles
  - --|--|GMA Particles
  - --|--|PLA Particles
  - --|--|PCL Particles
  - --|--|PLLA Particles
  - --|--|PDLA Particles
  - --|--|PLGA Particles
  - --|--|PTFE Particles
  - --|--|PBS Particles
- Other Particles
  - --|--|Upconverting Nanoparticles
  - --|--|Quantum dots
  - --|--|Fluorescent Particles
  - --|--|Chromatography Media
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Rabbit anti-Human Chk2 Monoclonal Antibody

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Citations

Cat No	BMA-641
Conjugate
Type	重组兔多抗
Source	Rabbit
Size	50 uL
Application	WB
Format	Liquid
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Species	Human
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Synonyms	CDS1;CHK2;HuCds1;LFS2;PP1425;RAD53;hCds1;CHEK2;Chk2
Purification	Affinity purification
MolecularWeight	65KDa
Description
Background	In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Rabbit anti-Human Chk2 Monoclonal Antibody