Rabbit anti-Human Huntingtin Monoclonal Antibody-Monoclonal Antibody-Biotyscience

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Antibodies
- Primary Antibodies
  - --|--|Monoclonal Antibody
  - --|--|Polyclonal Antibody
  - --|--|Small Molecule Antibody
  - --|--|Antibody Pairs
- Secondary Antibodies
- ELISA Kit
  - --|--|Conjugation Kit
Protein
Bioparticles
- Metal Nanoparticles
  - --|--|Gold Nanoparticles
  - --|--|Gold Nanorods
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  - --|--|Gold NanoUrchins
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  - --|--|Special Shape Particles
- Magnetic Particles
  - --|--|PS Magnetic Particles
  - --|--|Silica Magnetic Particles
  - --|--|Fe3O4 Magnetic Particles
  - --|--|Functionalized Magnetic Particles
  - --|--|Magnetic Particles Conjugates
  - --|--|Fe2O3 Magnetic Particles
  - --|--|Magrose Magnetic Particles
  - --|--|UF Magnetic Particles
  - --|--|Conjugation Kit
  - --|--|Other Magnetic Particles
  - --|--|Magnetic Separation
- Monodisperse Particles
  - --|--|Polystyrene Particles
  - --|--|Silica Particles
  - --|--|PMMA Particles
  - --|--|PET Particles
  - --|--|PVA Particles
  - --|--|PVC Particles
  - --|--|DVB Particles
  - --|--|PP Particles
  - --|--|PE Particles
  - --|--|GMA Particles
  - --|--|PLA Particles
  - --|--|PCL Particles
  - --|--|PLLA Particles
  - --|--|PDLA Particles
  - --|--|PLGA Particles
  - --|--|PTFE Particles
  - --|--|PBS Particles
- Other Particles
  - --|--|Upconverting Nanoparticles
  - --|--|Quantum dots
  - --|--|Fluorescent Particles
  - --|--|Chromatography Media
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Rabbit anti-Human Huntingtin Monoclonal Antibody

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Documentation
Citations

Cat No	BMA-995
Conjugate
Type	重组兔多抗
Source	Rabbit
Size	50 uL
Application	Immunogen
Format	Liquid
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Species	Human
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Synonyms	HD;IT15;HTT;Huntingtin
Purification	Affinity purification
MolecularWeight	350kDa
Description
Background	Huntingtin is a disease gene linked to Huntingtons disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntingtons disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5 UTR that inhibits expression of the huntingtin gene product through translational repression.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Rabbit anti-Human Huntingtin Monoclonal Antibody