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Mouse Anti-CD47 Monoclonal Antibody (Fluor 488), clone SA-007
- Description
- Documentation
- Citations
| Cat No | BSMA-0055 |
| Conjugate | |
| Type | Monoclonal Antibody |
| Source | Mouse |
| Tag | Fluor 488 |
| Size | 100 ug |
| Application | FC |
| Format | Liquid |
| Concentration | Please refer to the vial lable for the specific concentration. |
| Buffer | Supplied in 0. 02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68. 98% PBS. |
| Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
| Synonyms | Antigen identified by monoclonal 1D8;Antigenic surface determinant protein OA3;CD 47;CD47;CD47 antigen (Rh-related antigen, integrin-associated signal transducer);CD47 antigen;CD47 glycoprotein;CD47 molecule;CD47_HUMAN;IAP;Integrin Associated Protein;Integrin associated signal transducer;Integrin-associated protein;Leukocyte surface antigen CD47;MER 6;MER6;OA 3;OA3;OTTHUMP00000041152;OTTHUMP00000041153;Protein MER6;Rh related antigen;Surface antigen identified by monoclonal 1D8 |
| Purification | Protein affinity purified. |
| Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| MolecularWeight | 35 kDa |
| Description | |
| Background | CD47 is an integral membrane protein that plays a role in the regulation of cation fluxes across cell membranes. Specifically, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to the extracellular matrix. It is also a receptor for the C-terminal cell binding domain of thrombospondin (SIRP). Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. CD47 is absent from Rh-null erythrocytes, but does play a role in cell adhesion in non-erythroid cells and may prevent premature elimination of erythrocytes. It may also be involved in membrane permeability changes following viral infection. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. CD47 is expressed on hemopoietic cells, epithelial cells, endothelial cells and fibroblasts and is strongly expressed in brain and mesenchymal cells. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.