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Rabbit Anti-Cytokeratin 17 Monoclonal Antibody (Fluor 594), clone SA-009

Cat NoBSMA-0057
Conjugate
TypeRecombinant Rabbit Monoclonal Antibody
SourceRabbit
TagFluor 594
Size100 ug
ApplicationIF
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 0. 02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68. 98% PBS.
StorageStore at -20 degree. Avoid repeated freeze/thaw cycles.
SynonymsCK 17;CK-17;Cytokeratin-17;K17;K1C17_HUMAN;Keratin 17;keratin 17 epitope S1;keratin 17 epitope S2;keratin 17 epitope S4;Keratin 17, type I;Keratin;Keratin type I cytoskeletal 17;keratin, type i cytoskeletal 17 [version 1];Keratin-17;KRT17;PC;PC2;PCHC1;type I cytoskeletal 17
PurificationProtein A affinity purified.
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight48 kDa
Description
BackgroundCytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.