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Rabbit Anti-Cytokeratin 1 Monoclonal Antibody (Fluor 488), clone SA-019
- Description
- Documentation
- Citations
| Cat No | BSMA-0067 |
| Conjugate | |
| Type | Recombinant Rabbit Monoclonal Antibody |
| Source | Rabbit |
| Tag | Fluor 488 |
| Size | 100 ug |
| Application | IF |
| Format | Liquid |
| Concentration | Please refer to the vial lable for the specific concentration. |
| Buffer | Supplied in 0. 02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68. 98% PBS. |
| Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
| Synonyms | 67 kDa cytokeratin;CK-1;CK1;Cytokeratin-1;Cytokeratin1;EHK;EHK1;Epidermolytic hyperkeratosis 1;EPPK;Hair alpha protein;K1;K2C1_HUMAN;Keratin;Keratin type II cytoskeletal 1;Keratin-1;Keratin1;KRT 1;Krt1;KRT1A;NEPPK;type II cytoskeletal 1;Type II keratin Kb1;Type-II keratin Kb1 |
| Purification | Protein A affinity purified. |
| Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| MolecularWeight | 66 kDa |
| Description | |
| Background | Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.