Biotyscience Inc
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Cat No | BSMA-0078 |
Conjugate | |
Type | Recombinant Rabbit Monoclonal Antibody |
Source | Rabbit |
Tag | Fluor 488 |
Size | 100 ug |
Application | IF, ICC |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 0. 02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68. 98% PBS. |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | CK 17;CK-17;Cytokeratin-17;K17;K1C17_HUMAN;Keratin 17;keratin 17 epitope S1;keratin 17 epitope S2;keratin 17 epitope S4;Keratin 17, type I;Keratin;Keratin type I cytoskeletal 17;keratin, type i cytoskeletal 17 [version 1];Keratin-17;KRT17;PC;PC2;PCHC1;type I cytoskeletal 17 |
Purification | Protein A affinity purified. |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | 48 kDa |
Description | |
Background | Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract. |