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Rabbit Anti-ALS2CL Polyclonal Antibody

Cat NoBSPA-0811
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationELISA; IHC
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
SpeciesHuman
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsALS2 C-terminal like,RN49018
Purification
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
BackgroundMutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases , including juvenile primary lateral sclerosis , a recessive form of amyotrophic lateral sclerosis , infantile onset ascending hereditary spastic paralysis and a form of complicated hereditary spastic paraplegia . The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein, which is associated with small, punctate membrane structures. Therefore Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal like protein also modulates Rab5 activity.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.