Rabbit Anti-CDKN1A Polyclonal Antibody-Products-Biotyscience

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Rabbit Anti-CDKN1A Polyclonal Antibody

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Citations

Cat No	BSPA-1604
Conjugate
Type	Polyclonal Antibody
Source	Rabbit
Size	1 mg
Application	ELISA; WB; IHC
Format	Liquid
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS.
Species	Human
Storage	Store at -20 degree. Avoid repeted freeze/thaw cycl.
Synonyms	CDKN1A;P21;CIP1;SDI1;WAF1;CAP20;CDKN1;MDA-6;p21CIP1
Purification
Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
Background	This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Rabbit Anti-CDKN1A Polyclonal Antibody