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Cat No | BSPA-2351 |
Conjugate | |
Type | Polyclonal Antibody |
Source | Rabbit |
Size | 1 mg |
Application | ELISA; IHC |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Species | Human |
Storage | Store at -20 degree. Avoid repeted freeze/thaw cycl. |
Synonyms | NLRC4;NLR family, CARD domain containing 4;CLAN;IPAF;CLAN1;CLANA;CLANB;CLANC;CLAND;CARD12 |
Purification | |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains . Human Ced4 homologs include APAF1 , NOD1/CARD4 , and NOD2/CARD15 . These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats . CARD12 is a member of the Ced4 family and can induce apoptosis. |