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Rabbit Anti-VHL Polyclonal Antibody

Cat NoBSPA-3002
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationELISA; IHC
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
SpeciesHuman
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsVHL;von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase;von Hippel Lindau syndrome , von Hippel Lindau tumor suppressor;von Hippel-Lindau disease tumor suppressor;VHL1;protein G7;elongin binding protein;RCA1;pVHL;HRCA1
Purification
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
BackgroundVon Hippel-Lindau syndrome is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor , which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.