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Cat No | BSPA-0794 |
Conjugate | |
Type | Polyclonal Antibody |
Source | Rabbit |
Size | 1 mg |
Application | ELISA; WB |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Species | Human |
Storage | Store at -20 degree. Avoid repeted freeze/thaw cycl. |
Synonyms | alkB homolog 5, RNA demethylase;ABH5;OFOXD;OFOXD1 |
Purification | |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N6-methyladenosine RNA, the most prevalent internal modification of messenger RNA in higher eukaryotes. Can also demethylate N6-methyladenosine in single-stranded DNA . Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3-UTR mRNAs in male germ cells. |