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Rabbit Anti-C4A/B Polyclonal Antibody

Cat NoBSPA-1375
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationWB; IHC-P; ELISA
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsC4A/B;C4A;CO4;CPAMD2;Complement C4-A;Acidic complement C4;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2;C4B;CO4;CPAMD3;Complement C4-B;Basic complement C4;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
Purification
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
BackgroundThis gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.