Rabbit Anti-FLT3 Polyclonal Antibody-Products-Biotyscience

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Rabbit Anti-FLT3 Polyclonal Antibody

Description
Documentation
Citations

Cat No	BSPA-1880
Conjugate
Type	Polyclonal Antibody
Source	Rabbit
Size	1 mg
Application	ELISA; WB; IHC
Format	Liquid
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS.
Species	Human
Storage	Store at -20 degree. Avoid repeted freeze/thaw cycl.
Synonyms	FLT3;fms-related tyrosine kinase 3;FLK2;STK1;CD135;FLK-2;receptor-type tyrosine-protein kinase FLT3;STK-1;CD135 antigen;FL cytokine receptor;fetal liver kinase 2;fms-like tyrosine kinase 3;stem cell tyrosine kinase 1;growth factor receptor tyrosine kinase type III
Purification
Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
Background	This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Rabbit Anti-FLT3 Polyclonal Antibody