Antibody-oligonucleotide conjugation technology combines the high precision of siRNA/ASO with the targeting ability and biodistribution characteristics of antibodies, thereby leveraging the advantages of both technologies. The natural or modified oligonucleotide conjugating to the antibody (covalent attachment by chemical and biological methods) is advantageous over traditional oligonucleotide structural modifications. Antibody-oligonucleotide conjugates or AOCs belong to a class of chimeric molecules whose structure combines two important families of biomolecules: monoclonal antibodies and oligonucleotides. Oligonucleotide-antibody conjugates have been used as the most suitable tool for high-sensitivity protein detection.
Biotyscience can provide high-quality antibody-oligonucleotide conjugation services using raw materials provided by customers; at the same time, our experienced scientists can meet your specific oligonucleotide conjugation needs with the highest efficiency and best quality.
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Website: www.biotyscience.com Phone: + 400-669-8850 Email: biotyscience@gmail.com
Basic Principles：
Using the third generation conjugation labeling technology, the antibody reacts with LINK NHS ester to introduce LINK into the antibody. In addition, the amine-modified oligonucleotide reacts with NHS ester to introduce NHS ester into the structure of the oligonucleotide. At the same time, after purification, they react with each other immediately to produce an antibody-oligonucleotide conjugate with a stable ring connection.
Technological Advantage
Enhanced label specificity
Very high sensitivity
Suitable for trace protein detection
Application of AOCs
Immuno-PCR (iPCR): antibody?DNA conjugate
Proximity ligation assay (PLA)
Proximity extension assay (PEA)
Immuno-HCR
Multiple immunohistochemistry
Single cell proteomics
Targeting therapeutics
Performed by trained professionals
Fast turnaround time
Full technical support
Evidence of successful conjugation provided
Conjugate at required antibody–oligo ratio and scale
High levels of antibody and oligo recovery so you save precious reagents
Ordering Information
Website: www.biotyscience.com
Phone: +86-400-669-8850
Email: biotyscience@gmail.com