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Cat No | BSA-0048A |
Conjugate | |
Type | Autoimmune Diseases |
Source | Synthetic |
Tag | BSA |
Size | 1 mg |
Application | Immunogen |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Cyclic Citrullinated Peptide;CCP;环瓜氨酸肽;277748-59-1;Cycliccitrullinatedpeptide;HQCHQESTXGRSRGRCGRSGS Disulfide bond |
Purification | |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | Rheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis and has a high teratogenic rate. High disability rate; In 2000, Dutch scholar Schellekens et al. reported for the first time that synthetic cyclic citrullinated peptide (CCP) was used as an antigen to detect antibodies in sera of RA patients. Anti-ccp antibodies are secreted spontaneously by B lymphocytes of patients with rheumatoid arthritis, but not by B lymphocytes of patients with other diseases and normal people. Using CCP as antigenic matrix to detect anti-CCP antibodies in serum of rheumatoid patients has high sensitivity (50%) and specificity (96%) for rheumatoid arthritis (RA), which is a highly specific index for the early diagnosis of RA. |