Biotyscience Inc
E-mail biotyscience@gmail.com
info@biotyscience.com
Tel 400-669-8850
Cat No | ADMD-056 |
Conjugate | |
Type | 重组蛋白 |
Source | HEK293 |
Tag | Fc,Myc,His |
Size | 1mg |
Application | Immunology |
Format | Liquid |
Purity | >95 %, SDS-PAGE |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS |
Species | Human |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | CD200R, CD200R1, CRTR2, HCRTR2, MOX2R, OX2R |
Purification | Protein A/G |
Note | For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. |
MolecularWeight | 55.3 kDa |
Description | |
Background | CD200R1 encodes a receptor for the OX-2 membrane glycoprotein, an Ig superfamily transmembrane glycoprotein expressed on the surface of myeloid cells; it can also be induced in certain T-cell subsets. CD200R1 interacts with CD200, which is also an Ig superfamily transmembrane glycoprotein, to down regulate myeloid cell functions. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. CD200 is expressed on the surface of a variety of cells including neurons, epithelial cells, endothelial cells, fibroblasts, lymphoid cells, and astrocytes. The regulation of CD200R1 signaling can occur by posttranslational modification—namely, phosphorylation of tyrosines in the CD200R1 cytoplasmic tail—or by the inducible expression or downregulation of either CD200R1 or CD200. |