Recombinant Human TIGIT protein,His-Recombinant Protein-Biotyscience

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Recombinant Human TIGIT protein,His

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Cat No	ADMD-083
Conjugate
Type	重组蛋白
Source	HEK293
Tag	His
Size	1mg
Application	Immunology
Format	Liquid
Purity	>90 %, SDS-PAGE
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS
Species	Human
Storage	Store at -20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	T cell immunoreceptor with Ig and ITIM domains, TIGIT, VSIG9, VSTM3, WUCAM
Purification	Protein A/G
Note	For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
MolecularWeight	13.9 kDa
Description
Background	T cell immunoreceptor with Ig and ITIM domains(TIGIT), also named as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane do-maincontaining protein 3 (VSTM3) and Washington University cell adhesion molecule (WUCAM), is a co-inhibitory molecule belonging to the immunoglobulin superfamily that was first discovered in 2009. It consists of an extracellular immunoglobulin variable (IgV) domain, a type I transmembrane domain and an intracellular domain with an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoglobulin tail tyrosine (ITT)-like motif. TIGIT is an inhibitory receptor expressed on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer immunotherapy is currently widely being investigated in both pre-clinical and clinical studies. In multiple cancers TIGIT is expressed on tumor-infiltrating cytotoxic T cells, helper T cells, regulatory T cells and NK cells, and its main ligand CD155 is expressed on tumor-infiltrating myeloid cells and upregulated on cancer cells, which contributes to local suppression of immune-surveillance.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Human TIGIT protein,His