Biotyscience Inc
E-mail biotyscience@gmail.com
info@biotyscience.com
Tel 400-669-8850
Cat No | BIOP020 |
Conjugate | |
Type | Recombinant Protein |
Source | N/A |
Tag | N/A |
Size | 0.1ml |
Application | Immunology |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | PBS |
Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
Synonyms | rhEGF;rh-Epidermal growth factor;Recombinant full length EGF protein. Beta urogastrone;Epidermal Growth Factor;URG;Urogastrone;EGF;EGF_HUMAN;Epidermal Growth Factor;HOMG4;OTTHUMP00000219721;OTTHUMP00000219722. |
Purification | Affinity chromatography |
MolecularWeight | 6.2KDa |
Description | |
Background | Function : Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. |