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Recombinant Protein

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Recombinant human EGF?Protein

Cat NoBIOP020
Conjugate
TypeRecombinant Protein
SourceN/A
TagN/A
Size0.1ml
ApplicationImmunology
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferPBS
StorageStore at -20 °C. Avoid repeated freeze/thaw cycles.
SynonymsrhEGF;rh-Epidermal growth factor;Recombinant full length EGF protein. Beta urogastrone;Epidermal Growth Factor;URG;Urogastrone;EGF;EGF_HUMAN;Epidermal Growth Factor;HOMG4;OTTHUMP00000219721;OTTHUMP00000219722.
PurificationAffinity chromatography
MolecularWeight6.2KDa
Description
BackgroundFunction : Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.