Recombinant Mouse TNFRSF4/OX40 Protein(aa 20-211), Fc-Recombinant Protein-Biotyscience

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Recombinant Mouse TNFRSF4/OX40 Protein(aa 20-211), Fc

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Cat No	BIOP2286
Conjugate
Type	免疫检查点
Source	HEK293
Tag	Fc
Size	10 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4
Species	Mouse
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	Tumor necrosis factor receptor superfamily member 4;Tnfrsf4;OX40;CD134;Txgp1
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description	aa 20-211
Background	OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamilywhich plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed onCD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation byCD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur whenactivated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokineproduction, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals arecritical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interactionregulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

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Recombinant Mouse TNFRSF4/OX40 Protein(aa 20-211), Fc