Recombinant Mouse PD-L2/B7-DC/CD273 Protein(aa 20-219), Fc-Recombinant Protein-Biotyscience

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Recombinant Mouse PD-L2/B7-DC/CD273 Protein(aa 20-219), Fc

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Cat No	BIOP2287
Conjugate
Type	免疫检查点
Source	HEK293
Tag	Fc
Size	10 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in 20mM PB, 150mM NaCl, pH 7.4.
Species	Mouse
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	Programmed cell death 1 ligand 2;Pdcd1lg2;PD-1 ligand 2;PD-L2;PDCD1 ligand 2;B7-DC;CD273;
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description	aa 20-219
Background	Programmed cell death 1 ligand 2 (PD-L2)belongs to the member of B7 family which can regulate theactivation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1), and the other is PD-L1. These two ligands shares 34% aa sequence identity.The mouse PD-L2 gene is highly expressed in heart,placenta, pancreas, lung and liver while expressed weakly in spleen, lymph nodes and thymus. Besides, theexpression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cellsunder CSF2 and IL4/interleukin-4 treatment, and up-regulated by IFNG/IFN-gamma stimulation in monocytes.PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signalwhich is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expressionof PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells, at both the induction andeffector phase of antitumor immunity. Moreover, PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.

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Recombinant Mouse PD-L2/B7-DC/CD273 Protein(aa 20-219), Fc