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Recombinant Mouse CD155/PVR Protein(aa 29-348), His

Cat NoBIOP2289
Conjugate
Type免疫检查点
SourceHEK293
TagHis
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS, pH 7.4.
SpeciesMouse
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsPoliovirus receptor;CD155 antigen;Nectin-like protein 5;Nectin-2;Tage4 receptor;Pvr;PVR;Necl5;CD155
Purification> 95% by SDS-PAGE.
MolecularWeight
Descriptionaa 29-348
BackgroundMouse poliovirus receptor (PVR, CD155) is a type I transmembrane (TM) glycoprotein that is a member of thenectin-related family of adhesion proteins within the immunoglobulin superfamily. It binds other moleculesincluding vitronectin, Nectin3, DNAM1, CD96, and TIGIT, but does not bind homotypically. CD155 includes a 28aa signal sequence, a 318 aa extracellular domain (ECD) with one N-terminal V-type and two C2-type Ig-likedomains, a 24 aa TM segment and a 38 aa cytoplasmic tail. Epithelial, endothelial, and many immune cellsshow low CD155 expression. It is up-regulated on endothelia by IFN γ , and is highly expressed on immaturethymocytes, lymph node dendritic cells, and tumor cells of epithelial and neuronal origin. On migrating cells, itis concentrated at the leading edge, where it binds basement membrane vitronectin, recruits Nectin-3-expressing cells, and cooperates with PDGF and integrin αvβ3 to promote cell migration. Binding of monocyteDNAM-1 to endothelial cell CD155 promotes transendothelial migration. Enhanced CD155 expression in tumorcells contributes to loss of contact inhibition and increased migration, but also allows tumor cell recognitionand killing by DNAM-1or CD96 expressing NK cells.
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