Recombinant Mouse CD155/PVR Protein(aa 29-348), His-Recombinant Protein-Biotyscience

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Recombinant Mouse CD155/PVR Protein(aa 29-348), His

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Cat No	BIOP2289
Conjugate
Type	免疫检查点
Source	HEK293
Tag	His
Size	10 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4.
Species	Mouse
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	Poliovirus receptor;CD155 antigen;Nectin-like protein 5;Nectin-2;Tage4 receptor;Pvr;PVR;Necl5;CD155
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description	aa 29-348
Background	Mouse poliovirus receptor (PVR, CD155) is a type I transmembrane (TM) glycoprotein that is a member of thenectin-related family of adhesion proteins within the immunoglobulin superfamily. It binds other moleculesincluding vitronectin, Nectin3, DNAM1, CD96, and TIGIT, but does not bind homotypically. CD155 includes a 28aa signal sequence, a 318 aa extracellular domain (ECD) with one N-terminal V-type and two C2-type Ig-likedomains, a 24 aa TM segment and a 38 aa cytoplasmic tail. Epithelial, endothelial, and many immune cellsshow low CD155 expression. It is up-regulated on endothelia by IFN γ , and is highly expressed on immaturethymocytes, lymph node dendritic cells, and tumor cells of epithelial and neuronal origin. On migrating cells, itis concentrated at the leading edge, where it binds basement membrane vitronectin, recruits Nectin-3-expressing cells, and cooperates with PDGF and integrin αvβ3 to promote cell migration. Binding of monocyteDNAM-1 to endothelial cell CD155 promotes transendothelial migration. Enhanced CD155 expression in tumorcells contributes to loss of contact inhibition and increased migration, but also allows tumor cell recognitionand killing by DNAM-1or CD96 expressing NK cells.

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Recombinant Mouse CD155/PVR Protein(aa 29-348), His