Recombinant Mouse CTLA-4/CD152 Protein(aa 37-161), Fc-Recombinant Protein-Biotyscience

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Recombinant Mouse CTLA-4/CD152 Protein(aa 37-161), Fc

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Cat No	BIOP2288
Conjugate
Type	免疫检查点
Source	HEK293
Tag	Fc
Size	10 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4.
Species	Mouse
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA-4;CD152;Ctla4
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description	aa 37-161
Background	Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Withinthe ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cellcostimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells.CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4is also found inregulatory T cells and may play an important role in their functions. T cell activation through theT cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have beenassociated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac diseasetype3(CELIAC3) and Hepatitis B virus infection(HBVinfection).

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Mouse CTLA-4/CD152 Protein(aa 37-161), Fc