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Recombinant Rat PD-L1/B7-H1/CD274 Protein(aa 18-238), His

Cat NoBIOP2292
Conjugate
Type免疫检查点
SourceHEK293
TagHis
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS,pH 7.4.
SpeciesRat
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsB7-H;B7H1;B7-H1;B7H1PDCD1L1;CD274 antigenMGC142294;CD274 molecule;CD274;PDCD1L1;PDCD1LG1;PDL1;PD-L1;PD-L1B7 homolog 1;PDL1PDCD1 ligand 1;programmed celldeath 1 ligand 1;Programmed death ligand 1
Purification> 95% by SDS-PAGE.
MolecularWeight
Descriptionaa 18-238
BackgroundPD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells includingmacrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety ofcarcinomas and melanoma. PD-L1 binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation andproliferation and induces the apoptosis of activated T cells. It plays a role in the development of immunetolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors thedevelopment of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development ofTh17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances thetumorigenic function of Th22 cells.
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