Content
Contact us
Biotyscience Inc
E-mail biotyscience@gmail.com
info@biotyscience.com
Tel 400-669-8850
Recombinant Human Kallikrein 1 Protein(aa 1-262), His
- Description
- Documentation
- Citations
| Cat No | BIOP2435 |
| Conjugate | |
| Type | 其他蛋白 |
| Source | HEK293 |
| Tag | His |
| Size | 20 ug |
| Application | Immunogen |
| Format | Lyophilized |
| Concentration | Please refer to the vial lable for the specific concentration. |
| Buffer | Supplied in PBS, pH 7.4. |
| Species | Human |
| Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
| Synonyms | hK1;Klk6;KLKR |
| Purification | > 95% by SDS-PAGE. |
| MolecularWeight | |
| Description | aa 1-262 |
| Background | This protein is the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.