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Recombinant Protein

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Recombinant Human TWEAK/TNFSF12 Protein

Cat NoBIOP2674
Conjugate
Type其他蛋白
SourceE. coli
Size20 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS, pH 7.4.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsTNFSF12;APO3L;DR3LG;TWEAK;TNLG4A
Purification> 95% by SDS-PAGE.
MolecularWeight
Description
BackgroundTNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.
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