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Recombinant Protein

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Cat No: BIOP2928 

Size: 10 ug 

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Recombinant Mouse B7-H3/CD276 Protein(aa 29-244), His

Cat NoBIOP2928
Type生物标志物
SourceHEK293
TagHis
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS, pH 7.4.
SpeciesMouse
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsCD276 antigen;CD276;B7 homolog 3;B7-H3;CD276
Purification> 95% by SDS-PAGE.
Descriptionaa 29-244
BackgroundCD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions inextracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with otherB7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine boneformation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providingfurther evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed onT-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts,fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature alsocorrelates with poor survival in patients, suggesting that it may play a role in tumor cell migration.
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