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Recombinant Human MANF Protein(aa 25-182), His

Cat NoBIOP3137
Conjugate
Type生长因子
SourceE. coli
TagHis
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 20mM PIPES, 500mM NaCl, pH 6.0.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsARMET;ARP
Purification> 92% by SDS-PAGE.
MolecularWeight
Descriptionaa 25-182
BackgroundThe protein is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing this protein increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.