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Recombinant Human Pre-B-Cell Colony-Enhancing Factor 1/PBEF/Visfatin Protein(aa 1-491), His
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| Cat No | BIOP3406 |
| Conjugate | |
| Type | 细胞因子 |
| Source | E. coli |
| Tag | His |
| Size | 10 ug |
| Application | Immunogen |
| Format | Lyophilized |
| Concentration | Please refer to the vial lable for the specific concentration. |
| Buffer | Supplied in 20mM HEPES, 150mM NaCl, pH 8.0. |
| Species | Human |
| Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
| Synonyms | Pre-B cell-enhancing factor;Nicotinamide phosphoribosyltransferase;NAmPRTase;Nampt;Pre-B-cell colony-enhancing factor 1;Visfatin;NAMPT;PBEF;PBEF1 |
| Purification | > 95% by SDS-PAGE. |
| MolecularWeight | |
| Description | aa 1-491 |
| Background | Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonalexpansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellularenzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “ visfatin ” . PBEF is constitutivelyexpressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular andextracellular forms. Most of the intracellular functions of PBEF are due to its role as a Nampt which can induceangiogenesis through upregulation of VEGF and VEGFR and secretion of MCP-1. Extracellular PBEF has beenshown to increase inflammatory cytokines, such as TNF- α , IL-1 β , IL-16, and TGF- β 1. PBEF also increases theproduction of IL-6, TNF- α , and IL-1 β in CD14+ monocyctes, macrophages, and dendritic cells, enhances theeffectiveness of T cells. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.