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Rabbit Anti-8-OHdG/DNA/RNA Damage Polyclonal Antibody

Cat NoBPA-959
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size0.1 ml
ApplicationELISA; IHC; IF
FormatLiquid
Concentration1 mg/ml
Buffer0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms8 Hydroxyguanosine;8-Hydroxy-2'-deoxyguanosine;8-Hydroxydeoxyguanosine;8 hydroxy 2’ deoxyguanosine;8 hydroxyguanine;8 hydroxyguanosine;8 OHG;8-OHG;8OG;8OHdG;8OHG;8 Oxoguanine;8 hydroxyguanine;8 Oxo 7,8 dihydroguanine;8 oxo Gua;8 oxoG.
PurificationProtein A
MolecularWeight0.283kDa
Description
Background8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease. Function: Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.