Biotyscience Inc
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Cat No | BSPA-0534 |
Conjugate | |
Type | Polyclonal Antibody |
Source | Rabbit |
Size | 1 mg |
Application | IHC-P; WB |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Storage | Store at -20 degree. Avoid repeted freeze/thaw cycl. |
Synonyms | JV18;MADH2;MADR2;JV18-1;hMAD-2;hSMAD2;LDS3;LDS1C;MADH3;JV15-2;HSPC193;HsT17436;Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;Mad-related protein 2;SMAD family member 2;SMAD 2;Smad2;JV15-2;SMAD 3;hMAD-2;SMAD 2 |
Purification | |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | Receptor-regulated SMAD that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |