Rabbit Anti-alpha Internexin Polyclonal Antibody-Polyclonal Antibody-Biotyscience

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Rabbit Anti-alpha Internexin Polyclonal Antibody

Description
Documentation
Citations

Cat No	BSPA-0804
Conjugate
Type	Polyclonal Antibody
Source	Rabbit
Size	1 mg
Application	WB; IHC-P; ICC/IF; IP; FC
Format	Liquid
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS.
Storage	Store at -20 degree. Avoid repeted freeze/thaw cycl.
Synonyms	INA;NEF5;NF-66;TXBP-1;alpha Internexin
Purification
Note	Tis product l is eeze eezeleezeegrrch useeze ly, no useeze huma, apeut agnost apcal.
MolecularWeight
Description
Background	Alpha-internexin is a Class IV intermediate filament originally discovered as it co-purifies with other neurofilament subunits. Alpha-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition, recent studies show a marked up-regulation of alpha-internexin during neuronal regeneration. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest. Recently Cairns et al. used this antibody to show that alpha-internexin is an abundant component of the inclusions of neurofilament inclusion body disease (NFID), a serious human neurodegenerative disorder. The antibody was also used to confirm the presence of circulating auto-antibodies to alpha-internexin in the sera of some patients with endocrine autoimmunity, as well as in some normal individuals.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Rabbit Anti-alpha Internexin Polyclonal Antibody