Biotyscience Inc
E-mail biotyscience@gmail.com
info@biotyscience.com
Tel 400-669-8850
Cat No | BSPA-1052 |
Conjugate | |
Type | Polyclonal Antibody |
Source | Rabbit |
Size | 1 mg |
Application | WB; IHC-P; ICC/IF; FC |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Storage | Store at -20 degree. Avoid repeted freeze/thaw cycl. |
Synonyms | Apoptosis signal- regulating kinase 1;ASK-1;MAP3K5;ASK1;MAPKKK5;MEK kinase 5;MEKK5;mitogen-activated protein kinase kinase kinase 5 |
Purification | |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | Mitogen-activated protein kinase signaling cascades include MAPK or extracellular signal-regulated kinase , MAPK kinase , and MAPK kinase kinase . MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 in vitro, and activates c-Jun N-terminal kinase /stress-activated protein kinase during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. |