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Rabbit Anti-BEST1 Polyclonal Antibody

Cat NoBSPA-1230
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationELISA; WB; IHC
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
SpeciesHuman
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsBEST1;ARB;BMD;BEST;RP50;VMD2;TU15B;Best1V1Delta2
Purification
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
BackgroundThis gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy , also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.